The University of Minnesota, Twin Cities, has a dynamic and growing startup ecosystem. It interfaces with the venture capital environment through initiatives such as the Minnesota Innovation Corps (MIN-Corps), a program designed to foster and accelerate technology commercialization.

The University of Minnesota Venture Center, part of the Office for Technology Commercialization, has played a pivotal role in the growth of the startup ecosystem. Since its inception in 2006, it has launched more than 160 startups based on University of Minnesota research technologies. In 2018 alone, the Venture Center launched a record 19 startup companies.

One of the university's notable success stories includes Calyxt, a company specializing in the development of healthier food products through gene-editing technology. Launched in 2010, Calyxt went public in 2017, making it one of the most recognized university startups.

The Holmes Center for Entrepreneurship is a further initiative that drives the entrepreneurial spirit within the university. It offers courses, workshops, and other practical experiences to students and has been instrumental in fostering the entrepreneurial culture on campus.

Notable investors and founders who have ties to the university include Robert Pohlad, a University of Minnesota alum and part of the Pohlad family that owns various businesses, including the Minnesota Twins. He is an active investor in numerous startups.

Overall, the University of Minnesota, Twin Cities, is nurturing a potent startup and venture capital ecosystem. Thanks to its supportive initiatives and successful alumni, it continues to contribute significantly to the larger Minnesota and Midwest startup scene.