Imperial College London has a robust startup and venture capital ecosystem, nurtured by institutions such as Imperial Innovations, Imperial Enterprise Lab, and the Imperial College Business School. These initiatives offer a range of services from seed funding to mentorships, aimed at promoting entrepreneurship and innovation within the University community.

Imperial Innovations, a subsidiary of Imperial College London, is an active player in the University's startup ecosystem. It provides seed funding, strategic advice, and partnerships to student or academic led businesses. The company has a successful track record of working with startups like Revolut, a digital bank started by alumni Nikolay Storonsky and Vlad Yatsenko. As of 2021, Revolut has over 15 million customers worldwide and a valuation of 5.5 billion dollars.

Another protagonist in the entrepreneurship ecosystem is the Imperial Enterprise Lab. It provides a host of services to help students start their own businesses. This includes startup weekend events, a Venture Catalyst Challenge for seed funding, and other startup support services. A notable example of Imperial Enterprise Lab's success is Vaccitech, a biotech startup co-founded by alumnus Adrian Hill. The company helped develop the COVID-19 vaccine with Oxford University and AstraZeneca.

The Imperial College Business School plays a significant role through the Imperial Venture Mentoring Service. This initiative pairs students and alumni with experienced entrepreneurs and investors who provide them with guidance to develop their startups. Moreover, the business school's entrepreneurship studies provide a theoretical and practical framework for students to start their own businesses.

Unique to Imperial's VC ecosystem is the Imperial College Investment Fund, a student-led venture capital fund. It provides startups with early-stage funding and gives students the opportunity to gain hands-on experience in venture capital.

Imperial College London's alumni have a strong presence in the global startup sector. DeepMind co-founder Demis Hassabis and Yoyo Wallet co-founder Michael Rolph are among the notable alumni who have achieved global recognition for their entrepreneurial endeavors.