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Lewis & Clark Ventures is an early-stage venture capital firm founded in St. Louis, Missouri, by former founders and operators John McConnell and Brian Thompson. Established to support entrepreneurs in building innovative B2B software companies, the firm has grown to manage over $200 million across three funds. The firm emphasizes investment in regions often overlooked by coastal venture funds, aiming to foster growth and innovation in the Midwest.
Currently, Lewis & Clark Ventures has a portfolio of 40 companies, reflecting its commitment to identifying and nurturing high-potential startups. The firm operates from its office located at 120 South Central Avenue, Suite 1000, St. Louis, MO 63105. Notable milestones include becoming one of the most active venture capital firms in the Midwest, particularly in the St. Louis corridor.
The investment strategy of Lewis & Clark Ventures centers on late seed through Series A funding for B2B software companies. The firm typically invests between $2 million and $3 million, with some flexibility in either direction. This approach allows them to support a diverse range of startups, particularly in sectors such as SaaS, healthcare, fintech, biotech, and agtech.
Lewis & Clark Ventures prioritizes companies located in geographies that are often overlooked by traditional coastal venture funds. Their thesis emphasizes partnering with dynamic founders who are building transformative software solutions. The firm seeks entrepreneurs who demonstrate strong leadership potential and a clear vision for growth, ensuring that they can navigate the challenges of scaling their businesses effectively.
Lewis & Clark Ventures has invested in a diverse array of companies, showcasing its commitment to various sectors within the B2B software landscape. Notable portfolio companies include:
This portfolio reflects the firm's focus on high-growth potential companies that are positioned to make significant impacts in their respective industries.
Tom Hillman: Founding General Partner with extensive experience in venture capital and entrepreneurship.
Max Hillman: Operating Partner, bringing operational expertise and strategic insights to portfolio companies.
Meg Lane: CFO & CCO, responsible for financial strategy and corporate communications.
Johanna Mennona: Associate, focusing on deal sourcing and due diligence.
Meghan Norman: Talent Manager, specializing in recruitment and talent development for portfolio companies.
David Poldoian: Operating Partner, providing operational support and guidance to startups.
Michael Rockhold: Principal, involved in investment analysis and portfolio management.
Tim Spihlman: Managing Director, overseeing investment strategy and firm operations.
Jessie Chapel: Investor Relations Manager, managing relationships with limited partners and stakeholders.
Courtney Moffat: Chief of Staff, supporting firm operations and strategic initiatives.
To pitch Lewis & Clark Ventures, founders should utilize the preferred channel of email at info@lacventures.com or through their contact page at this link. A comprehensive pitch deck should include details about the business model, market opportunity, competitive landscape, and team qualifications. Founders can expect a response within a reasonable timeframe, but specific timelines may vary based on the volume of inquiries.
As of March 2026, Lewis & Clark Ventures continues to be active in the venture capital space, focusing on investments in B2B software companies. The firm has made over 40 investments, solidifying its position as one of the most active VCs in the Midwest. Recent activities include ongoing support for portfolio companies and strategic guidance to help them scale effectively.
While specific exits have not been detailed, the firm remains committed to fostering innovation and growth within its portfolio, particularly in sectors such as healthcare and agtech.
What are the investment criteria for Lewis & Clark Ventures?
Lewis & Clark Ventures invests in late seed through Series A B2B software companies, typically providing initial funding between $2 million and $3 million. They focus on sectors such as SaaS, healthcare, fintech, biotech, and agtech.
How can founders apply or pitch to Lewis & Clark Ventures?
Founders can reach out through the firm's contact page at this link or via email at info@lacventures.com. A well-prepared pitch deck that outlines the business model, market opportunity, and team is essential.
What makes Lewis & Clark Ventures different from other firms?
The firm is founded by former founders and operators, which allows them to provide unique operational support and strategic guidance to their portfolio companies. They focus on regions often overlooked by coastal venture funds, aiming to foster innovation in the Midwest.
What is the geographic scope of Lewis & Clark Ventures?
Lewis & Clark Ventures primarily invests in the United States, with a specific focus on the Midwest and regions that may lack access to traditional venture funding.
What is the firm's post-investment involvement like?
The firm adds value through strategic guidance, operational support, and access to a network of industry connections, helping entrepreneurs navigate challenges and scale their businesses effectively.
What is the typical check size for investments?
Lewis & Clark Ventures typically invests between $2 million and $3 million in initial funding, with some flexibility depending on the specific needs of the startup.
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