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Wireframe Ventures is a venture capital firm founded in 2016 in San Francisco, California. The firm specializes in investing in early-stage technology companies that aim to create a healthier and more sustainable future. With a current fund size of $77 million, Wireframe Ventures has established itself as a key player in the venture capital landscape, focusing on sectors that address critical global challenges.
As of 2025, Wireframe Ventures has invested in over 33 companies, demonstrating a strong commitment to supporting founders with a clear vision and purpose. The firm emphasizes diversity and inclusion, with 67% of its portfolio companies led by first-time founders and 38% by female or underrepresented minority entrepreneurs. Notable milestones include the successful backing of unicorns such as Enveda Biosciences and the acquisition of Electriphi by Ford.
Wireframe Ventures primarily invests in seed and pre-seed stage startups within the climate technology, biotechnology, and healthcare sectors. The firm typically invests between $500,000 and $2 million, seeking scalable solutions to climate change and advancements in healthcare through innovative technologies. Their investment thesis emphasizes the integration of AI and automation to enhance these solutions.
The firm looks for founders who are driven by a clear vision and purpose, focusing on companies that address critical global challenges. Wireframe Ventures has a strong preference for early-stage investments, often participating from pre-seed through subsequent funding rounds, as evidenced by their involvement in Enveda Biosciences from pre-seed to Series D.
Wireframe Ventures has a diverse portfolio of 33 companies, with notable investments including:
These companies reflect Wireframe's commitment to investing in technologies that address climate change and healthcare advancements.
Paul Straub: Co-Founder and Managing Director at Wireframe Ventures. He has a background in venture capital and has led notable investments in the health and sustainability sectors.
Harsh Patel: Co-Founder and Managing Director. He brings extensive experience in technology investments and has a strong focus on early-stage companies.
Lily Bernicker: Partner at Wireframe Ventures, specializing in biotech investments. She has a proven track record of supporting startups in the life sciences sector.
To pitch Wireframe Ventures, founders should submit their proposals through the firm's website at wireframevc.com. The pitch deck should include a clear overview of the business model, market opportunity, and the team behind the startup. Founders are encouraged to highlight any traction or milestones achieved to date.
Response times may vary, but founders can expect to hear back within a few weeks. Warm introductions are preferred, but not mandatory.
In January 2025, Wireframe Ventures led a $12 million Series A investment in Bedrock Energy, following an earlier seed investment of $9 million in October 2023. In September 2025, they participated in a $150 million Series D round for Enveda Biosciences, which achieved unicorn status.
Wireframe Ventures has also been active in supporting Xcimer Energy, which received a DOE grant in 2023 for its laser-driven nuclear fusion technology. LevelTen Energy raised $65 million in 2024, with Wireframe Ventures as an early investor since its Series A in September 2017.
What are Wireframe Ventures' investment criteria?
Wireframe Ventures invests in seed and pre-seed stage startups primarily in the climate technology, biotechnology, and healthcare sectors. They typically invest between $500,000 and $2 million.
How can founders apply or pitch to Wireframe Ventures?
Founders can apply through the Wireframe Ventures website at wireframevc.com or send inquiries to info@wireframevc.com.
What makes Wireframe Ventures different from other VC firms?
Wireframe Ventures emphasizes a strong commitment to diversity and inclusion, with a significant portion of their portfolio comprising first-time founders and underrepresented minority entrepreneurs. They also focus exclusively on health and sustainability sectors.
What is Wireframe Ventures' geographic scope?
The firm primarily invests in startups located in North America.
What is Wireframe Ventures' post-investment involvement?
Wireframe Ventures provides strategic guidance, access to a network of industry experts, and support in securing follow-on funding for their portfolio companies.
What is the typical check size for investments?
Wireframe Ventures typically invests between $500,000 and $2 million in their portfolio companies.
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