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San Diego startup ecosystem

Explore documented companies, programs, research institutions, and investors connected to San Diego. Superscout does not promise local investment access.

Population
1,394,928
Time zone
America/Los_Angeles
Fig. 1412 · Torrey Pine

About

San Diego is a vibrant city for startups, particularly in the biotechnology, healthcare and technology sectors. One of the leading factors is the presence of many quality research institutions, like the University of California, San Diego (UCSD) and the Scripps Research Institute which fuels the biotech and healthcare startups scene.

Companies such as Illumina, worth $47 billion, back their roots to San Diego. Illumina, a biotech company, revolutionized DNA sequencing and its headquarters are still based in San Diego.

Another successful startup with San Diego roots is Qualcomm. Its founder, Irwin Jacobs, continues to be a significant figure in the local scene through his philanthropic activities and investments. Qualcomm, a mobile technology company, was founded in San Diego in 1985 and has grown into a multinational semiconductor and telecommunications equipment corporation.

In addition to these established companies, San Diego has a thriving venture capital ecosystem. With companies like Section 32, a venture capital firm founded by Bill Maris, who is originally from San Diego and was the founder of Google Ventures, is contributing significantly to the city’s VC landscape. Their main purpose is to invest in biotech, healthcare and technology startups that aren't in traditional tech hubs.

A local initiative of note is EvoNexus, a technology incubator in San Diego. This non-profit organization has helped numerous San Diego startups grow and raise funds. They provide mentoring, office space, and strategic start-up assistance to emerging companies for a period of two years without taking any equity.

San Diego, through its mix of startups, venture capitalists, incubators, and academic institutions, is making its mark on the global map as a growing startup hub. The city's blend of sunshine, innovation, and investment makes it a prime location for entrepreneurs and investors.

This month

On in San Diego this month

13 startup events in the next 30 days, 1 this week, 12 free. The city as a calendar, with the hosts and venues that keep it full.

All events in San Diego

Wednesday, Nov 4

Saturday, Nov 7

Growing Good Saturday

Barron Creek Farm · Barron Creek Farm
Free

Sunday, Nov 8

Venture Week San Diego

Christopher Carew · San Diego
Free

SDxSDSU Voice Agent Hackathon

Hackathon · SDxSDSU · Engineering & Interdisciplinary Science (EIS)
Free

Wednesday, Nov 11

Farm Friends Wednesdays

Barron Creek Farm · Barron Creek Farm
Free
Regular hostsAJ Caldwell · 2Barron Creek Farm · 2KindsMeetups · 3Hackathons · 1Workshops · 1

Startup ecosystem standing

Where San Diego ranks

Rankings that list San Diego
RankingEditionPositionSince last editionTrustWhat it measures
Global Innovation Index: Innovation Cluster Ranking (formerly Science and Technology Clusters)2026#14No changeBInnovation, Research, Activity
Global Startup Ecosystem Report (GSER)GSER 2026#17Up 2CEcosystem, Performance, Finance, Talent, Innovation
Global Startup Ecosystem Index (cities)2025#25No prior editionBEcosystem, Activity, Finance, Business Climate
Global Cities Index2026#37No prior editionBPerformance, Growth, Talent, Competitiveness, Business Climate
Global Financial Centres IndexGFCI 40#53No changeBFinance, Competitiveness, Business Climate
Positions come from each publisher's edition. Open a ranking for its method and trust notes, or an edition for the full list.

190 organizations with a profile

Who's based in San Diego

Investors 138

Qualcomm Ventures logoInvestor

Empowering technology innovation through strategic investments.

NuFund Venture Group logoInvestor

Empowering technology innovators with flexible capital and expert mentorship.

The 3 most prominent of 138. Browse all investors

Incubators 19

EvoNexus logoIncubator

Empowering startups in Southern California.

REC Innovation Lab logoIncubator

Empowering diverse entrepreneurs to launch scalable tech startups.

The 3 most prominent of 19. Browse all incubators

Venture studios 18

The 3 most prominent of 18. Browse all venture studios

Accelerators 15

Connect logoAccelerator

Connect is a non-profit organization based in San Diego, established in 1985, that supports entrepreneurs and companies in the life sciences and…

HomeLab logoAccelerator

HomeLab is a leading deep bio accelerator based in California, focused on helping startups in Longevity, BioAI, and Quantum fields commercialize…

OPTYO logoAccelerator

Accelerating brands in sports, fitness, and wellness.

The 3 most prominent of 15. Browse all accelerators

Based here, most-ranked first

Universities in San Diego

Pick what describes you

Your way in

From public sources

What the sources say about San Diego

Questions about San Diego

How does San Diego rank as a startup ecosystem?

San Diego is #25 of 1,473 in StartupBlink Index (cities) (2025). It appears in 5 published rankings; the table above lists each one.

How many startup investors are based in San Diego?

138 investors based in San Diego have a profile here, including Qualcomm Ventures, NuFund Venture Group and Shepherd Ventures. The real number is higher.

Are there accelerators or incubators in San Diego?

Yes. San Diego has 15 accelerators, 19 incubators and 18 venture studios on record, including Connect, EvoNexus and Unlimit Ventures.

Which universities are in San Diego?

One university has a profile: UC San Diego.

Geographic proximity

Nearby cities to San Diego

All cities in United States

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