InvestorEmpowering technology innovation through strategic investments.
Explore documented companies, programs, research institutions, and investors connected to San Diego. Superscout does not promise local investment access.
San Diego is a vibrant city for startups, particularly in the biotechnology, healthcare and technology sectors. One of the leading factors is the presence of many quality research institutions, like the University of California, San Diego (UCSD) and the Scripps Research Institute which fuels the biotech and healthcare startups scene.
Companies such as Illumina, worth $47 billion, back their roots to San Diego. Illumina, a biotech company, revolutionized DNA sequencing and its headquarters are still based in San Diego.
Another successful startup with San Diego roots is Qualcomm. Its founder, Irwin Jacobs, continues to be a significant figure in the local scene through his philanthropic activities and investments. Qualcomm, a mobile technology company, was founded in San Diego in 1985 and has grown into a multinational semiconductor and telecommunications equipment corporation.
In addition to these established companies, San Diego has a thriving venture capital ecosystem. With companies like Section 32, a venture capital firm founded by Bill Maris, who is originally from San Diego and was the founder of Google Ventures, is contributing significantly to the city’s VC landscape. Their main purpose is to invest in biotech, healthcare and technology startups that aren't in traditional tech hubs.
A local initiative of note is EvoNexus, a technology incubator in San Diego. This non-profit organization has helped numerous San Diego startups grow and raise funds. They provide mentoring, office space, and strategic start-up assistance to emerging companies for a period of two years without taking any equity.
San Diego, through its mix of startups, venture capitalists, incubators, and academic institutions, is making its mark on the global map as a growing startup hub. The city's blend of sunshine, innovation, and investment makes it a prime location for entrepreneurs and investors.
This month
13 startup events in the next 30 days, 1 this week, 12 free. The city as a calendar, with the hosts and venues that keep it full.
Wednesday, Nov 4
Saturday, Nov 7
Sunday, Nov 8
Wednesday, Nov 11
Startup ecosystem standing
| Ranking | Edition | Position | Since last edition | Trust | What it measures |
|---|---|---|---|---|---|
| 2026 | #14 | No change | B | Innovation, Research, Activity | |
| GSER 2026 | #17 | Up 2 | C | Ecosystem, Performance, Finance, Talent, Innovation | |
| 2025 | #25 | No prior edition | B | Ecosystem, Activity, Finance, Business Climate | |
| 2026 | #37 | No prior edition | B | Performance, Growth, Talent, Competitiveness, Business Climate | |
| GFCI 40 | #53 | No change | B | Finance, Competitiveness, Business Climate |
190 organizations with a profile
InvestorEmpowering technology innovation through strategic investments.
InvestorEmpowering technology innovators with flexible capital and expert mentorship.
InvestorInvesting in growth companies in tech and life sciences.
The 3 most prominent of 138. Browse all investors
IncubatorEmpowering startups in Southern California.
IncubatorEmpowering student entrepreneurs to launch startups.
IncubatorEmpowering diverse entrepreneurs to launch scalable tech startups.
The 3 most prominent of 19. Browse all incubators
Venture studioBuilding businesses from ambitious concepts.
Venture studioWe create world-class entrepreneurs ®
Venture studioCreating and launching new companies.
The 3 most prominent of 18. Browse all venture studios
AcceleratorConnect is a non-profit organization based in San Diego, established in 1985, that supports entrepreneurs and companies in the life sciences and…
AcceleratorHomeLab is a leading deep bio accelerator based in California, focused on helping startups in Longevity, BioAI, and Quantum fields commercialize…
AcceleratorAccelerating brands in sports, fitness, and wellness.
The 3 most prominent of 15. Browse all accelerators
Pick what describes you
Investors based here, and the programs that take teams at your stage.
Get investor introsAccelerators and incubators here see the earliest teams first.
Get startups that fitCampuses and communities are where teams form before anyone funds them.
Start scoutingFrom public sources
The timeline identifies Dexcom’s 2018 no-draw glucose monitoring milestone.
Source: 100 years of innovation: How San Diego became a hub for life-changing breakthroughsThe timeline dates Illumina to 1998 and identifies its genomics tools focus.
Source: 100 years of innovation: How San Diego became a hub for life-changing breakthroughsThe regional timeline identifies Hybritech as a San Diego-founded biotech in 1978.
Source: 100 years of innovation: How San Diego became a hub for life-changing breakthroughsShield AI reported $240 million financing at a $5.3 billion valuation in March 2025.
Source: Shield AI raises $240M at $5.3B valuationSDMAC describes i4NS as student commercialization work focused on DoD problems.
Source: Spotlight: San Diego’s Innovation EconomySDMAC describes specialist defense startup capital paths as fragmented.
Source: Spotlight: San Diego’s Innovation EconomySan Diego is #25 of 1,473 in StartupBlink Index (cities) (2025). It appears in 5 published rankings; the table above lists each one.
138 investors based in San Diego have a profile here, including Qualcomm Ventures, NuFund Venture Group and Shepherd Ventures. The real number is higher.
Yes. San Diego has 15 accelerators, 19 incubators and 18 venture studios on record, including Connect, EvoNexus and Unlimit Ventures.
One university has a profile: UC San Diego.
Superscout Pro
Is this page right?How the research works