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U.S. Venture Partners (USVP) is a prominent venture capital firm founded in 1981 and headquartered in Menlo Park, California. With over 40 years of experience, USVP has established itself as a key player in the early-stage investment landscape, particularly within the technology and healthcare sectors. The firm has successfully raised a total of $4.3 billion in invested capital since its inception, demonstrating a robust commitment to supporting innovative entrepreneurs. USVP's reputation is built on its extensive network of industry professionals and a proven track record of successful investments, which includes 233 portfolio exits as of late 2025. This impressive history positions USVP as one of the original Silicon Valley venture firms, known for its strategic insights and deep expertise in navigating the complexities of early-stage investments.
U.S. Venture Partners primarily invests in early-stage companies across various sectors, including SaaS, cloud technologies, cybersecurity, consumer technology, and healthcare. The firm is particularly focused on the transition to SaaS and cloud solutions, pioneering investments in security technologies that enhance consumer experiences. In the healthcare domain, USVP targets innovative medical devices, biotechnology, and healthcare IT, emphasizing therapeutic solutions that can significantly impact patient care. The firm typically invests between $5 million and $10 million, supporting companies at various stages from pre-seed to Series B+. USVP seeks to partner with visionary entrepreneurs who are committed to transforming their ideas into impactful businesses, leveraging its extensive resources and industry connections to facilitate growth and innovation.
U.S. Venture Partners boasts a diverse portfolio of approximately 400 companies, showcasing its extensive reach and influence in the venture capital space. Notable investments include industry leaders such as Box, Guidewire, and Yammer, alongside emerging companies like Espagon, Human Interest, and Zerto. The firm has a strong track record of successful exits, with 233 portfolio exits recorded, including significant companies like Informed and Raken. This impressive portfolio reflects USVP's strategic focus on sectors poised for growth and innovation, particularly in technology and healthcare. By investing in a wide range of companies, USVP not only diversifies its investment strategy but also enhances its ability to support entrepreneurs across various stages of their business journeys.
To pitch U.S. Venture Partners, founders should email their proposals to contact@usvp.com. It is recommended to include a concise overview of the business, highlighting the unique value proposition, market potential, and team qualifications. USVP is open to both warm introductions and cold applications, but a well-prepared pitch is essential for consideration.
Recently, U.S. Venture Partners has been actively engaged with its portfolio, highlighting significant funding rounds for companies such as Slang AI, which raised $36 million in a Series B round, and Adaptive6, which has emerged from stealth mode. These activities underscore USVP's commitment to supporting innovative startups and its ongoing involvement in the venture ecosystem.
What stages does U.S. Venture Partners invest in?
U.S. Venture Partners invests in a range of stages from pre-seed to Series B+, allowing them to support companies at various points in their growth journey.
How do I pitch U.S. Venture Partners?
Founders can pitch U.S. Venture Partners by reaching out via their contact email at contact@usvp.com. It is advisable to provide a clear and concise overview of the business, including the problem being solved, market opportunity, and team background.
What sectors does U.S. Venture Partners focus on?
U.S. Venture Partners primarily focuses on sectors such as SaaS, cloud technologies, cybersecurity, consumer technology, and healthcare, including medical devices and biotechnology.
What is U.S. Venture Partners' typical check size?
The typical check size for U.S. Venture Partners ranges from $5 million to $10 million, allowing them to make significant investments in promising startups.
Where does U.S. Venture Partners invest geographically?
U.S. Venture Partners has a geographic focus that includes North America and global markets, enabling them to tap into a wide array of innovative startups.
What portfolio support does U.S. Venture Partners provide?
U.S. Venture Partners adds value to its portfolio companies by leveraging its extensive network of industry professionals, providing strategic guidance, and facilitating connections that can accelerate growth and innovation.
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