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Epsilon Health Investors, LLC is a venture capital firm based in Washington, DC, specializing in digital healthcare. Founded in 2017 by healthcare veterans Steven Epstein and Gregory Epstein, the firm manages capital on behalf of strategic limited partners and commercial investors. Epsilon Health Investors aims to address inefficiencies in the healthcare system by supporting innovative companies in the digital health sector.
The firm has established a strong presence in the venture capital landscape, focusing on Seed+ to Series B investments. Epsilon Health Investors has a diverse portfolio that includes companies across various U.S. hubs such as Chicago, New York, Cleveland, Washington DC, Los Angeles, Sunnyvale, Boston, and Redwood City. The firm’s strategic limited partners include health systems, health plans, and healthcare organizations, enhancing the support available to its investments.
Notable milestones include successful exits such as Luma Health and wayForward, showcasing the firm’s ability to identify and nurture promising startups. Epsilon Health Investors continues to evolve, leveraging its extensive network and expertise to drive innovation in the digital health space.
Epsilon Health Investors employs a thematic investment strategy, concentrating on digital health companies that tackle significant challenges within the healthcare landscape. The firm invests primarily in Seed+ to Series B stages, with a keen interest in healthcare IT and technology-enabled services. Epsilon is open to leading investment rounds or participating in syndicates, providing both capital and strategic insights to its portfolio companies.
The firm specifically targets companies that address inefficiencies in the healthcare system, focusing on areas such as clinical AI, patient engagement, and cybersecurity for healthcare. Epsilon Health Investors seeks startups that can scale with strategic healthcare customers and demonstrate a clear fit within health-system workflows. This approach allows the firm to leverage its extensive network and expertise to support innovative solutions that improve healthcare delivery.
Epsilon Health Investors has a diverse portfolio of companies, including:
Other notable companies in their portfolio include IgniteData, KODE Health, Marigold, and Praia Health, each contributing to the firm's focus on digital health innovation.
Greg Epstein: General Partner, Co-Founder. Greg has extensive experience in healthcare investing and advisory roles, previously associated with Epstein Becker & Green, P.C.
Steven Epstein: General Partner, Co-Founder. Steven is a healthcare veteran with a strong background in venture capital and strategic healthcare investments.
Steve Brady: Partner. Steve brings a wealth of experience in healthcare investments and operational support for portfolio companies.
Taylor Whitman: Partner. Taylor focuses on identifying and supporting innovative healthcare startups within the firm’s investment thesis.
Kaitlynne Brock: Finance Director. Kaitlynne oversees financial operations and reporting for the firm.
Andrew Lutes: Associate. Andrew supports the investment team in sourcing and evaluating potential portfolio companies.
Advisors include Leslie Norwalk, David Hillis, David Pitts, Ted Kennedy Jr., Teri Fontenot, Fran Green, William A. Keyes IV, PhD, and Richard P. Burke, each bringing valuable insights from their respective backgrounds in healthcare and policy.
In 2026, Epsilon Health Investors participated in a $10 million Series A funding round for AvoMD, a clinical AI platform that translates clinical evidence into workflows at the point of care.
Additionally, Epsilon Health Investors has successfully exited from investments in Luma Health and wayForward, showcasing their ability to identify and support promising startups in the digital health sector.
What are Epsilon Health Investors' investment criteria?
Epsilon Health Investors focuses on digital health companies addressing significant inefficiencies in the healthcare system. They invest primarily in Seed+ to Series B stages, particularly in healthcare IT and technology-enabled services.
How can I pitch to Epsilon Health Investors?
Founders can reach out through their official website or LinkedIn. A well-prepared pitch deck should include details about the problem being solved, market opportunity, and the team’s background.
What makes Epsilon Health Investors different from other VCs?
The firm has a unique focus on digital health and a strong network of strategic limited partners, including health systems and healthcare executives, which provides valuable insights and connections for portfolio companies.
What is the typical check size for investments?
While specific check sizes are not disclosed, Epsilon Health Investors typically invests in Seed+ to Series B rounds, indicating a range that aligns with early-stage funding.
What geographic areas does Epsilon Health Investors focus on?
The firm primarily invests in the United States, with a portfolio that includes companies from major hubs such as Chicago, New York, and Washington, DC.
What kind of support do portfolio companies receive post-investment?
Epsilon Health Investors provides commercial validation, regulatory insights, and introductions to key stakeholders across health systems, payers, and providers, enhancing the growth potential of their portfolio companies.
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