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Amplitude Ventures is a venture capital firm founded in 2026 and based in Canada. The firm specializes in creating, building, and growing precision medicine companies that enhance patient outcomes. Amplitude Ventures operates with a full-stack model, providing not only capital but also active participation in the development of its portfolio companies.
The firm has a total AUM of over $500 million, with its second fund, closed in May 2024, amounting to CAD $263 million (approximately $192 million USD). Amplitude Ventures has established offices in Montreal, Toronto, and Calgary, and it has a diverse LP base that includes CDPQ, Royal Bank of Canada, and Investissement Quebec.
Notable milestones include successful exits from Fund I, such as Repare Therapeutics, which went public on NASDAQ, and Valence, which was acquired by Recursion. The firm has been recognized for its commitment to precision medicine and its ability to scale biotech companies effectively.
Amplitude Ventures invests at the intersection of biology and machine learning, targeting companies in the biotech and healthcare sectors. The firm focuses on therapeutic areas including cardiology, drug discovery, immunology, metabolic diseases, neurology, neurovascular conditions, oncology, and rare diseases. Their investment strategy emphasizes early-stage companies, specifically in Seed, Series A, and Series B rounds.
The firm seeks to partner with founders who are passionate about improving patient outcomes through innovative diagnostics and treatments. Amplitude Ventures values a strong scientific foundation and a clear path to market for the technologies they support. They prefer to engage in co-investment opportunities and provide strategic guidance to help portfolio companies navigate challenges and scale effectively.
Amplitude Ventures has a diverse portfolio of companies that exemplify its focus on precision medicine and AI. Notable portfolio companies include:
These companies represent Amplitude's commitment to advancing healthcare through innovative solutions and technologies.
Jean-Francois Pariseau: Co-founder and partner at Amplitude Ventures, previously a partner at BDC Capital. He has extensive experience in venture capital and has led numerous successful investments in the biotech sector.
Dion Madsen: Co-founder and partner, also a former partner at BDC Capital. Madsen brings a wealth of knowledge in healthcare investments and has a strong track record of supporting early-stage companies.
To pitch Amplitude Ventures, founders should send an email to info@amplitudevc.com. It is important to include a comprehensive pitch deck that outlines the startup's vision, market opportunity, and team qualifications. While there are no specific application forms or portals mentioned, a well-structured email with relevant information is essential.
Response times may vary, but founders can expect to hear back within a few weeks. Warm introductions are preferred, as they can facilitate a more favorable review process.
In February 2026, Amplitude Ventures supported Radiant Biotherapeutics in scaling its operations. The firm co-led a $76 million Series B financing for Mediar Therapeutics, further solidifying its commitment to advancing precision medicine.
Amplitude Ventures has also made recent investments in Evommune, Tentarix Biotherapeutics, Reverb Therapeutics, and Evolved Therapeutics, all of which align with its focus on innovative healthcare solutions.
What are Amplitude Ventures' investment criteria?
Amplitude Ventures focuses on early-stage investments in the biotech and healthcare sectors, particularly in companies that operate at the intersection of biology and machine learning. They are interested in therapeutic areas such as cardiology, drug discovery, immunology, metabolic diseases, neurology, neurovascular conditions, oncology, and rare diseases.
How can founders apply or pitch to Amplitude Ventures?
Founders can pitch Amplitude Ventures by sending an email to info@amplitudevc.com. It is recommended to include a detailed pitch deck that outlines the business model, market opportunity, and team background.
What makes Amplitude Ventures different from other VC firms?
Amplitude Ventures distinguishes itself through its full-stack model, which not only provides capital but also actively participates in the development and growth of its portfolio companies. The firm leverages its expertise in precision medicine to offer strategic guidance and support.
What is the geographic scope of Amplitude Ventures?
Amplitude Ventures primarily invests in North America, with a strong focus on Canadian biotech and healthcare companies.
What is the typical check size for investments?
While specific check sizes are not disclosed, Amplitude Ventures invests in Seed, Series A, and Series B rounds, indicating a range that typically aligns with early-stage funding.
What kind of post-investment involvement does Amplitude Ventures have?
Amplitude Ventures is known for its active involvement in portfolio companies, providing strategic guidance, operational support, and assistance in navigating challenges to help companies scale effectively.
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