InvestorInvesting in transformative early-stage companies.
SL
Scout startups in St. Louis
Learn where early startup activity happens in St. Louis and how to turn local context into a stronger scouting practice.
- Country
- United States
- Population
- 315,685
- Time zone
- America/Chicago
Startup ecosystem standing
Where St. Louis ranks
| Ranking | Edition | Position | Since last edition | Trust | What it measures |
|---|---|---|---|---|---|
 Global Startup Ecosystem Index (cities) | 2025 | #118 | No prior edition | B | Ecosystem, Activity, Finance, Business Climate |
 Emerging Ecosystems Ranking (GSER Top 100) | 2026 | 51 to 60 | No prior edition | C | Ecosystem, Performance, Finance, Talent |
19 organizations with a profile
Who's based in St. Louis
Investors 10
Investor
InvestorCatalytic capital for life sciences innovation.
InvestorInvesting at the intersection of health, wealth, and privacy.
The 3 most prominent of 10. Browse all investors
Venture studios 5
Venture studioInnovating web products through design thinking.
Venture studioBuilding and scaling innovative tech products.
Venture studioBuilding the future of work in agriculture.
The 3 most prominent of 5. Browse all venture studios
Accelerators 3
AcceleratorEmpowering student-led healthcare innovations.
AcceleratorAccelerating Amazon PPC success for sellers.
AcceleratorEmpowering women entrepreneurs across the Commonwealth.
Incubators 1
IncubatorBuilding a 'Founder First, Innovation for All' community.
Based here, most-ranked first
Universities in St. Louis
UniversityPick what describes you
Your way in
Raising in St. Louis
Investors based here, and the programs that take teams at your stage.
Founder toolsFinding startups in St. Louis
Accelerators and incubators here see the earliest teams first.
Explore dealflowScouting in St. Louis
Campuses and communities are where teams form before anyone funds them.
Become a scoutQuestions about St. Louis
How does St. Louis rank as a startup ecosystem?
St. Louis is #118 of 1,473 in StartupBlink Index (cities) (2025). It appears in 2 rankings tracked on Superscout; the table above lists each one.
How many startup investors are based in St. Louis?
Superscout has profiles for 10 investors based in St. Louis, including Cultivation Capital, BioGenerator Ventures and SixThirty Ventures.
Are there accelerators or incubators in St. Louis?
Yes. Superscout lists 3 accelerators, 1 incubator and 5 venture studios based there, including Sling Health, StartupSTL and XD Holdings.
Which universities in St. Louis are on Superscout?
One university has a profile: Webster University.
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Following
Superscout documents St. Louis ecosystem information independently from canonical records and linked sources. Missing facts stay missing.
Sources and known limits
A reviewed date is not available for this page.
- StartupBlink 2026 report
- Global Startup Ecosystem Index (cities), 2025
- Emerging Ecosystems Ranking (GSER Top 100), 2026
Organizations are placed by their recorded headquarters (Google place, ROR or company record). Only organizations with a Superscout profile are counted, so totals undercount the full ecosystem.
The population value has no measurement date in the canonical record and should be treated as approximate context.
Superscout is not affiliated with, endorsed by, or acting on behalf of the organizations documented here.