InvestorInvesting in private markets for over 30 years.
SR One Capital Management
SR One Capital Management is a biotechnology venture capital firm based in Redwood City, California, and London, specializing in early-stage investments in life sciences companies. The firm employs a 'back-and-build' approach to support innovative therapeutics development.
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Where SR One Capital Management ranks
| Ranking | Edition | Listed as | Position | Since last edition | Trust | What it measures |
|---|---|---|---|---|---|---|
| Strebulaev-Jackson Venture Ranking: Top 50 Biotech VC Firms | 2026 | SR One | #21 | No prior edition | B | Performance |
Overview
SR One Capital Management is a transatlantic biotechnology venture capital firm founded in 1985, with its current independent structure established around 2020. The firm focuses on investing in and supporting companies in the life sciences sector, particularly in areas such as cardiometabolic diseases, oncology, immunology, and neuropsychiatry. SR One partners with founders and entrepreneurs to translate innovative science into effective treatments, using a 'back-and-build' investment approach that combines capital, company-building help, and access to scientific and operating networks. Notable portfolio companies include ADARx Pharmaceuticals, AirNexis Therapeutics, and CRISPR Therapeutics.
Focus
SR One invests in biotechnology companies across various sectors, including cardiometabolic, CNS, immunology, infectious disease, oncology, rare diseases, renal, and neuropsychiatry. The firm employs a back-and-build investment strategy, targeting companies at different stages of development, from clinical to preclinical.
Support
SR One adds value to its portfolio companies by providing capital, company-building support, and access to scientific and operational networks. The firm's transatlantic model enhances opportunities for collaboration and innovation in biotechnology.
Questions
What investment criteria does SR One Capital Management prioritize?
SR One focuses on biotechnology companies with strong fundamentals and clearly defined development pathways. They seek to partner with founders who are translating innovative science into effective medicines.
How can founders pitch to SR One?
Founders can reach out via email to initiate a conversation. It is advisable to include a detailed overview of the company, its technology, and the specific funding needs in the initial communication.
What stages of investment does SR One engage in?
SR One invests across multiple stages, including pre-seed, seed, seed-plus, Series A, Series B, and Series C. This allows them to support companies at various points in their development.
What geographic areas does SR One focus on?
The firm has a transatlantic presence, primarily focusing on opportunities in North America and Europe. This geographic scope enables them to access high-quality scientific advancements and investment opportunities.
What types of companies does SR One typically invest in?
SR One invests in biotechnology companies across sectors such as cardiometabolic diseases, oncology, immunology, infectious disease, rare diseases, renal, and neuropsychiatry. They are particularly interested in companies with innovative approaches to addressing diseases.
What is SR One's involvement post-investment?
SR One provides ongoing support to portfolio companies, leveraging its extensive network and expertise to assist in the development of novel therapeutics and navigating the complexities of the biotech landscape.
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