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SIIF Impact Capital, Inc. (SIIFIC) was founded on August 1, 2023, as a subsidiary of the Japan Social Innovation and Investment Foundation (SIIF). Headquartered in Shibuya, Tokyo, SIIFIC specializes in impact investing, particularly within the health and wellness sectors. The organization is committed to fostering next-generation industries that generate both economic and social value, especially in response to Japan's aging population.
As of late 2025, SIIFIC manages a total of approximately $23 million across its SIIFIC Wellness Fund, which was established to deploy institutional capital into the wellness sector. The fund has attracted commitments from notable limited partners, including Higo Bank, which contributed ¥500 million. SIIFIC operates as a professional investment manager, distinguishing itself from traditional venture capital firms by integrating rigorous Impact Measurement and Management (IMM) practices into its investment strategy.
SIIFIC's mission is to enhance wellness literacy and social capital in Japan, addressing systemic wellness inequities through innovations in healthcare, nutrition, and social capital. The organization has made significant strides in establishing itself as a key player in Japan's impact economy, leveraging its connections within the broader impact ecosystem.
SIIF Impact Capital focuses on impact investing in the health and wellness sectors, specifically targeting startups that enhance wellness literacy and social capital. The firm employs systems thinking and globally recognized impact investment methodologies to address social issues related to wellness, particularly in the context of Japan's demographic challenges. SIIFIC invests across seed, early, and pre-IPO stages, with a check size range that aligns with the needs of its portfolio companies.
The sectors of interest include healthcare, biotech, food-agtech, and climate. SIIFIC's investment thesis emphasizes achieving wellness equity, which involves addressing systemic inequities in wellness through innovative solutions. The organization seeks founders who demonstrate a strong commitment to social impact and possess the capability to drive systemic change within their respective industries. Deal structures often incorporate rigorous IMM practices to ensure that investments align with the firm's impact objectives.
SIIF Impact Capital's portfolio consists of four notable companies, each aligned with its focus on wellness equity:
These companies exemplify SIIFIC's commitment to investing in sectors that not only promise financial returns but also contribute positively to societal health and wellness.
Kazuhiro Umeda: Co-Founder & Representative Partner. Umeda has a background as the Founder and President of M3i, the corporate venture capital arm of Japan's largest digital healthcare company. He also served as Vice President at INCJ, Japan's largest government-backed open innovation fund, and held senior roles at Japan Asia Investment Co. His educational background includes a Master's degree from Tokyo University of Pharmacy and Life Sciences.
Reiri Miura: Co-Founder & Representative Partner. Miura has completed executive studies at Harvard Business School and Said Business School, Oxford. She has expertise in creating shared value (CSV) and impact investing. Miura and Umeda originally met during their postings in Silicon Valley and reconnected in early 2022 to co-found SIIFIC.
Nanako Kudo: Director. Kudo brings experience in managing investments and supporting portfolio companies, focusing on operational excellence and impact measurement.
Kenji Maekawa: Auditor. Maekawa oversees compliance and financial reporting, ensuring that SIIFIC adheres to its impact investment principles.
To pitch to SIIF Impact Capital, founders should use the contact form available on their website at Submit Pitch. It is recommended to include a detailed deck that outlines the startup's mission, business model, and social impact potential. Founders should expect a response within a few weeks, depending on the volume of submissions. Warm introductions are preferred but not mandatory, as the firm is open to reviewing pitches submitted through their website.
In October 2023, SIIF Impact Capital made its maiden investment in **ジェイファーマ株式会社 (Jay Pharma, Inc.)**, a biotech company developing LAT1 inhibitors for cancer treatment. This investment was selected from approximately 2,000 candidates, showcasing the firm's rigorous selection process.
In March 2024, SIIFIC invested in **ORTHOREBIRTH株式会社 (Orthorebirth, Inc.)**, a medical device startup known for its bioresorbable bone void filler, which has received approvals in multiple countries including the US and Japan.
In 2024, SIIFIC also invested in **Proximar株式会社 (Proximar, Inc.)**, which operates Japan's first large-scale land-based Atlantic salmon farm using recirculating aquaculture systems (RAS) technology.
In August 2025, the firm made an investment in **株式会社C-HASプラス (C-HAS Plus, Inc.)**, a biotech spin-off from Kumamoto University, focusing on health span analysis technology. This was followed by an investment in **株式会社Personal Health Tech (Personal Health Tech, Inc.)** in September 2025, which specializes in digital healthcare solutions.
What are SIIF Impact Capital's investment criteria?
SIIF Impact Capital invests in startups that enhance wellness literacy and social capital, particularly in the health and wellness sectors. The firm looks for innovative solutions that address systemic wellness inequities in Japan.
How can founders apply or pitch to SIIF Impact Capital?
Founders interested in pitching to SIIF Impact Capital can submit their proposals through the contact form available on their website at Submit Pitch.
What makes SIIF Impact Capital different from other venture capital firms?
SIIF Impact Capital is distinct in its focus on impact investing, specifically targeting wellness equity. The firm employs rigorous Impact Measurement and Management (IMM) practices and integrates social impact into its investment strategy.
What is the geographic scope of SIIF Impact Capital's investments?
SIIF Impact Capital primarily invests in Japan, focusing on startups that address local wellness challenges and contribute to the country's social capital.
What is the typical fund size and check size for investments?
The SIIFIC Wellness Fund has a total size of approximately $23 million, with investments made across seed, early, and pre-IPO stages. Check sizes vary based on the needs of the portfolio companies.
What kind of post-investment involvement does SIIF Impact Capital have?
SIIF Impact Capital actively engages with its portfolio companies through rigorous IMM practices, aiming to enhance their operational capabilities and promote systemic change in the wellness sector.
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