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One Eight Capital is a venture capital firm based in New York City, founded by Alexander Bussenger in late 2024. The firm was established with a clear mission to transform healthcare through personalized, preventative, and individualized care. The name 'One Eight' symbolizes a pivotal health event for Bussenger on January 8, 2024, reflecting a commitment to impactful healthcare innovation.
Currently, One Eight Capital manages a fund size of $50 million, with plans to scale to $100 million. The firm aims to build a portfolio of approximately 50 early-stage companies, focusing on sectors such as healthcare, digital health, biotech, and longevity. As of now, they have deployed around $5 million across three companies, indicating an active investment strategy.
One Eight Capital's office is located in New York City, positioning it strategically within a vibrant startup ecosystem. The firm is dedicated to partnering with visionary entrepreneurs who are redefining healthcare, particularly in the realms of genomics and wellness.
One Eight Capital invests primarily in early-stage companies that are pioneering advancements in healthcare. Their investment strategy emphasizes sectors such as healthcare, digital health, biotech, and longevity, with a particular focus on genomics and wellness. The firm participates in seed, Series A, and Series B funding rounds, typically writing checks in the range of $1 million to $2 million.
The firm’s investment thesis, termed 'Healthcare 3.0', aims to shift the paradigm from reactive 'sick care' to preventative and individualized medicine. One Eight Capital seeks to bridge the gap between consumer health and clinical-grade medical services, emphasizing preventative care and athlete wellness. Their advisory board, which includes notable figures like former NFL linebacker Ray Lewis and Buffalo Bills safety Damar Hamlin, provides unique insights and access to the athlete wellness sector.
One Eight Capital has invested in three notable companies:
These investments reflect One Eight Capital's commitment to supporting innovative companies that align with their focus on personalized and preventative healthcare.
Alexander Bussenger — Founder. Bussenger graduated from Canisius University in 2013 and has a background in private banking and financial services. He transitioned to early-stage healthcare investing, focusing on innovative healthcare solutions.
Advisory Board Members:
To pitch One Eight Capital, founders should send an email to alex@oneeightcapital.com. It is important to include a comprehensive pitch deck that outlines the business model, market opportunity, and alignment with One Eight's investment thesis.
Founders should expect a response within a few weeks, as the firm actively reviews incoming pitches. Warm introductions are preferred but not mandatory.
In January 2025, One Eight Capital participated in a $14 million Series A round for Nucleus Genomics, co-investing with notable firms like Founders Fund and Seven Seven Six. This investment aligns with their focus on genomics and personalized healthcare.
As of April 2026, One Eight Capital has actively deployed approximately $5 million across three companies, indicating a strong commitment to early-stage healthcare innovation.
What are One Eight Capital's investment criteria?
One Eight Capital focuses on early-stage companies in the healthcare sector, particularly those innovating in genomics, digital health, and wellness. They prefer to invest in businesses that emphasize preventative care and individualized medicine.
How can I pitch One Eight Capital?
Founders can reach out via email at alex@oneeightcapital.com. It is advisable to include a detailed pitch deck that outlines the business model, market opportunity, and how the startup aligns with One Eight's investment thesis.
What makes One Eight Capital different from other VCs?
One Eight Capital distinguishes itself through its focus on Healthcare 3.0 and its unique advisory board, which includes high-profile athletes. This positioning provides portfolio companies with enhanced credibility and access to the athlete wellness market.
What is the geographic focus of One Eight Capital?
The firm primarily invests in North America, specifically within the United States, allowing them to tap into a robust healthcare innovation ecosystem.
What is the typical check size for investments?
One Eight Capital typically invests between $1 million and $2 million in each portfolio company, aligning with their strategy to support early-stage ventures.
What kind of post-investment support does One Eight Capital provide?
One Eight Capital offers strategic guidance and access to a network of high-profile advisors, enhancing brand credibility and providing unique market insights for their portfolio companies.
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