Main Sequence

Main Sequence is a venture capital firm based in Australia, focusing on deep technology investments that address significant global challenges. Established by CSIRO, it bridges the gap between research and industry, managing over $1 billion in capital.

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Overview

Main Sequence is a venture capital firm founded in 2017 and based in Australia. It was established by CSIRO, Australia's national science agency, to support the commercialization of research by investing in spinouts, startups, and small to medium enterprises (SMEs) connected to Australia’s publicly funded research and development sector. The firm manages over $1 billion in capital, including the CSIRO Innovation Fund, which has completed investments in 51 companies. Main Sequence aims to bridge the gap between research and industry, facilitating the development of deep technology. The firm focuses on sectors such as space, healthcare, industrial productivity, and sustainable agriculture, investing from seed to Series B stages.

Focus

Main Sequence focuses on deep technology companies that address significant global challenges, investing from seed to Series B stages. The firm targets sectors such as space, healthcare, industrial productivity, and sustainable agriculture, with a commitment to supporting innovations that tackle issues like decarbonization, food security, and advanced intelligence.

Support

Main Sequence adds value by leveraging its connections with CSIRO and 28 Australian universities to bridge the gap between research and commercialization, providing strategic support and resources to portfolio companies.

Questions

What are Main Sequence's investment criteria?

Main Sequence focuses on deep technology companies that address significant global challenges. They invest in sectors such as AI, healthcare, climate, space-tech, industrial productivity, and agtech, targeting startups from seed to Series B stages.

How can I apply or pitch to Main Sequence?

Founders can pitch to Main Sequence through their website at mseq.vc. It is recommended to include a clear business model, market analysis, and how the startup addresses a significant global challenge in the pitch deck.

What makes Main Sequence different from other venture capital firms?

Main Sequence is unique due to its strong ties with CSIRO and 28 Australian universities, which enhances its ability to bridge the gap between research and commercialization. This connection allows them to support startups with valuable resources and insights.

What is the geographic scope of Main Sequence's investments?

Main Sequence invests globally, focusing on deep technology companies that can address challenges on an international scale.

What is the typical check size for investments?

While specific check sizes can vary, Main Sequence invests from seed to Series B stages, adapting their financial support to the needs of each startup.

What is Main Sequence's post-investment involvement like?

Main Sequence provides strategic support and resources to its portfolio companies, leveraging its extensive network to assist in commercialization and growth.

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