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F-Prime Capital is the venture capital arm of Fidelity Investments, established over 50 years ago and headquartered in Cambridge, Massachusetts. The firm also has offices in London and San Francisco, allowing it to maintain a global presence. F-Prime Capital manages approximately $4.8 billion in assets under management (AUM) and has built a portfolio that includes over 212 companies worldwide. The firm operates without the pressure of outside fundraising, enabling it to focus entirely on supporting entrepreneurs.
F-Prime Capital has a rich history in venture investing, particularly in the healthcare and technology sectors. The firm has achieved notable milestones, including successful exits with companies like Alibaba, Atari, and Ironwood Pharmaceuticals. Its investment strategy is characterized by a stage-agnostic approach, primarily targeting early-stage investments while remaining open to exceptional opportunities at any stage.
F-Prime Capital invests across various sectors, including biotech, fintech, healthcare, SaaS, therapeutics, medtech, enterprise software, and crypto. The firm typically writes checks ranging from $5 million to $30 million, focusing on companies in North America and Europe. Their investment strategy emphasizes healthcare and technology, leveraging Fidelity's extensive resources and expertise. F-Prime Capital's small, local teams are equipped with deep domain knowledge, allowing them to identify and support innovative companies effectively.
The firm’s thesis revolves around enabling breakthroughs in life sciences and technology, with a particular focus on healthtech. F-Prime Capital's lack of fundraising pressure allows them to concentrate fully on the needs of entrepreneurs, fostering scalable growth in their portfolio companies.
F-Prime Capital's portfolio includes several notable companies, reflecting its focus on transformative technologies:
Stephen Knight, MD: President & Senior Managing Partner with extensive experience in healthcare investments.
Rocio Wu: Partner with a background in technology and venture capital.
Carl Byers: Team Member with expertise in biotech investments.
Jon Lim: Team Member focused on technology startups.
David Jegen: Team Member with a strong background in healthcare.
Sarah Lamont: Team Member specializing in early-stage investments.
Gaurav Tuli: Team Member with experience in fintech.
Ben Gorman: Team Member with a focus on SaaS and technology.
To pitch F-Prime Capital, startups should submit their proposals through the contact form on their website. It is advisable to include a comprehensive deck that outlines the business model, market opportunity, and team background. Response times may vary, but founders can expect to hear back within a few weeks. Warm introductions are preferred but not mandatory.
F-Prime Capital offers a **Life Sciences Summer Fellowship** for MD and/or PhD students. This program runs for 10 weeks from June 8 to August 7, 2026, and provides a stipend ranging from $16,000 to $22,000. Applications are due by March 13, 2026, and interested candidates can apply through the firm's website.
On December 1, 2025, F-Prime Capital made its latest investment, continuing its active engagement in the venture capital space. Over the past 12 months, the firm has completed 10 investments, showcasing its commitment to supporting innovative companies across various sectors.
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What are F-Prime Capital's investment criteria?
F-Prime Capital focuses on early-stage investments in sectors such as healthcare, technology, biotech, fintech, and SaaS. They typically invest between $5 million and $30 million.
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How can startups apply or pitch to F-Prime Capital?
Startups can submit their pitch through the contact form on F-Prime Capital's website. They encourage detailed presentations that highlight the company's vision, market potential, and team.
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What makes F-Prime Capital different from other venture capital firms?
F-Prime Capital benefits from Fidelity's backing, which provides significant resources without the pressure of outside fundraising. This allows them to focus entirely on supporting entrepreneurs.
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What is F-Prime Capital's geographic scope?
F-Prime Capital primarily invests in North America and Europe, with a sister fund, Eight Roads, covering investment opportunities in Asia.
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What is F-Prime Capital's post-investment involvement like?
F-Prime Capital provides operational support and strategic guidance to its portfolio companies, leveraging its extensive network and resources.
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