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Founded in 2025, 25madison is a venture capital firm based in New York City, with an additional office in Boca Raton, Florida. The firm specializes in early-stage investments, focusing on AI-native software and tech-enabled businesses, and has a diverse portfolio across various sectors. 25madison also engages in transformation buyouts of lower-middle market companies.
25madison invests in pre-seed to Series A rounds, targeting early-stage opportunities in AI, healthcare, biotech, consumer, and commerce sectors. Their investment strategy includes providing incubation services for AI-native startups and acquiring businesses to enhance operational efficiencies through applied AI.
Notable portfolio companies include Basalt Health, an AI-powered healthcare assistant; Canopy, which offers wearable personal safety technology; and Clear, a pricing and payments platform for healthcare. Other investments include Flourish, a virtual mental health care service, and Kouper Health, discharge case management software for hospitals.
Submit your pitch through their form at 25madison.com or email your deck to team@25madison.com.
25madison runs a program focused on incubating AI-native startups, providing resources and support for early-stage companies looking to modernize traditional industries.
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